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DHEA Effective for Lupus.
A natural human hormone looks like it's on track to be the first new treatment approved for systemic lupus erythematosus in 40 years.
Prasterone, which is the hormone dehydroepiandrosterone (DHEA), was safe and effective for improving systemic lupus erythematosus (SLE) symptoms and cutting the need for steroids in a phase III trial of 346 women with mild to moderate disease, Dr. Robert G. Lahita reported at the annual meeting of the American College of Rheumatology in Philadelphia.
The drug was also effective in reversing the bone density loss often seen in women with SLE who are treated with a corticosteroid.
If approved by the Food and Drug Administration for this indication, prasterone would be appropriate as a first-line treatment for patients with mild to moderate disease, experts said. It will probably not be useful for patients with more severe disease, such as those with severe nephritis. Furthermore, until results are analyzed ...
- Prasterone reduces disease flares, improves blood lipid levels in clinical...
- Newspaper article from: OBGYN & Reproduction Week September 27, 2004 700+ words
...known generically as prasterone, does have validated...as a treatment for SLE, prasterone was recently shown to...treated with standard SLE therapies during the...significant improvement in the prasterone group is both statistically...
- GL701 (Prasterone) Significantly Reduces Lupus Flares.
- Press release article from: PR Newswire October 31, 2000 700+ words
...flares or exacerbations that systemic lupus erythematosus (SLE or lupus) patients experience, some resulting in hospitalization...study in Taiwan contains the same amount of active ingredient (prasterone) as in the GL701 used to support Genelabs Technologies, Inc...
- Genelabs Meets With FDA - Will Submit NDA for Gl701 for SLE.
- Press release article from: PR Newswire November 22, 1999 700+ words
...evident in the group of 137 SLE patients with active disease...DHEA) in patients with SLE. GL701 is a pharmaceutical preparation that contains prasterone, the pharmaceutical generic...adrenal glands. People with SLE generally have abnormally...
- Genelabs Technologies Participates in 7th International Congress on SLE and...
- Press release article from: PR Newswire May 6, 2004 700+ words
...investigational drug, Prestara(TM) (prasterone, Anastar(TM) in Europe...International Congress on SLE and Related Conditions which...systemic lupus erythematosus (SLE or lupus), Prestara improved or stabilized overall SLE disease activity and symptoms...
- SLE, a Tundra Division, Offers High-Speed Interlaken Interconnect Protocol IP...
- Press release article from: PR Newswire January 23, 2007 700+ words
...Silicon Logic Engineering Inc. (SLE), a high-end semiconductor design services...IP core for use in ASIC or FPGA designs. SLE's Interlaken IP Core is scalable, with...synthesizable into many ASIC and FPGA technologies, SLE's Interlaken IP Core was uniquely built...
- Pediatric SLE's course varies by ethnicity, age.(Musculoskeletal...
- Magazine article from: Family Practice News Worcester, Sharon October 1, 2008 700+ words
...without pediatric systemic lupus erythematosus (SLE) were white; however, fewer than 40% of the pediatric SLE patients were white. Black, Asian, and...patients are overrepresented in the pediatric SLE population, Dr. Earl Silverman reported...
- Tundra's SLE Division Announces Market's First 150 Gb/s Interlaken IP Core.
- Press release article from: PR Newswire February 27, 2008 700+ words
...Silicon Logic Engineering Inc. (SLE), a high-end semiconductor design services...protocol IP core for use in ASIC designs. SLE's new Interlaken IP Core is now available...variable number of SERDES lanes (1 to 24). SLE is currently shipping the new 150Gb/s...
- Ethnicity appears to affect SLE incidence, manifestations.(Across...
- Magazine article from: Clinical Psychiatry News Worcester, Sharon September 1, 2008 700+ words
...without pediatric systemic lupus erythematosus (SLE) were white; however, less than 40% of the pediatric SLE patients were white. Black, Asian, and...patients are overrepresented in the pediatric SLE population, Dr. Earl Silverman reported...
