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Remicade.
(infliximab, Centocor)
A tumor necrosis factor-[alpha] (TNF-[alpha]) blocker to inhibit progression of joint damage when used with methotrexate, in people with moderately to severely active rheumatoid arthritis with inadequate response to methotrexate. This is a newly approved claim; approved in 1999 for treating rheumatoid arthritis after inadequate response to methotrexate.
* Dosage: Intravenous infusions usually administered 2 and 6 weeks after an initial infusion, followed by an infusion every 8 weeks.
* Special Considerations: Serious infections, including sepsis and fatal infections have been reported in people on Remicade and Enbrel (etanercept), the other TNF blocker on the market.
* Comment: Approval of the new claim was based on results of a multicenter study of 428 predominantly white women with moderate to severe RA with active disease despite methotrexate treatment. Over 1 year, patients on Remicade and methotrexate had sustained reductions in RA signs and symptoms that significantly exceeded ...
- JOURNAL WATCH: Triple therapy limits RA joint damage.(rheumatoid arthritis...
- Newspaper article from: Pulse July 19, 2004 700+ words
...drug therapy limits peripheral joint damage in patients with early arthritis...with early, clinically active rheumatoid arthritis to receive methotrexate, sulfasalazine...that triple therapy limited joint damage for up to five years regardless...
- New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint...
- Press release article from: PR Newswire May 9, 2008 700+ words
...patients with rheumatoid arthritis (RA), a...Structural Joint Damage) trial showed...including joint damage and loss of...structural joint damage in 2009. ACTEMRA...treatment of rheumatoid arthritis, juvenile...
- Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression...
- Press release article from: PR Newswire June 9, 2009 700+ words
...a broad range of rheumatoid arthritis patient populations...Prevention of Structural Joint Damage) study demonstrated...greater proportion of rheumatoid arthritis (RA) patients treated...progression of structural joint damage compared with patients...
- Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint...
- Magazine article from: Annals of the Rheumatic Diseases Tchetverikov, I Lard, LR DeGroot, J Verzijl, N TeKoppele, JM Breedveld, FC Huizinga, TWJ Hanemaaijer, R November 1, 2003 700+ words
...recent onset rheumatoid arthritis (RA). Methods...the two years joint damage progressed...and severe joint damage progression...predictive of joint damage progression...Rheumatoid arthritis (RA) (1...
- New Study Demonstrated ACTEMRA(R) (tocilizumab) Inhibited Progression of Joint...
- Press release article from: PR Newswire October 28, 2008 700+ words
...progression of structural joint damage in patients with rheumatoid arthritis (RA). Late-breaking...ACTEMRA inhibited structural joint damage, which is a major cause...It is critical to stop joint damage as quickly as possible...
- Data demonstrated Actemra (tocilizumab) significantly inhibited progression of...
- News wire article from: Chemical Business Newsbase June 10, 2009 700+ words
...Prevention of Structural Joint Damage) study demonstrated...greater proportion of rheumatoid arthritis (RA) patients treated...progression of structural joint damage compared with patients...progression of structural joint damage, as measured by the...
- Data demonstrated ACTEMRA (tocilizumab) significantly inhibited progression of...
- News wire article from: Chemical Business Newsbase June 9, 2009 700+ words
...Prevention of Structural Joint Damage) study demonstrated...greater proportion of rheumatoid arthritis (RA) patients treated...progression of structural joint damage compared with patients...prevention of structural joint damage, improvement in physical...
- Analysis of Phase III Study Showed Rituxan(R) Plus Methotrexate Reduced Joint...
- Press release article from: PR Newswire June 22, 2006 700+ words
...Rituximab) in patients with rheumatoid arthritis (RA) who have had an inadequate...data to measure the progression of joint damage in this difficult-to-treat patient...About the Role of B-cells in Rheumatoid Arthritis While RA has traditionally been considered...
- Rheumatoid factor measured by fluoroimmunoassay: a responsive measure of...
- Magazine article from: Annals of the Rheumatic Diseases Knijff-Dutmer, E Drossaers-Bakker, W Verhoeven, A van der Sluijs Veer, G Boers, M van der Linden, S van de Laar M July 1, 2002 700+ words
...reflect disease activity in rheumatoid arthritis (RA). Further, to study...parameters with radiological joint damage, especially in individual...conclusions on its role in rheumatoid arthritis (RA) have not been drawn...
- Analysis of Phase III study showed Rituxan plus methotrexate reduced joint...
- News wire article from: Chemical Business Newsbase June 22, 2006 700+ words
...clinical study of Rituxan (Rituximab) in patients with rheumatoid arthritis (RA) who have had an inadequate response to previous...These are the first data to measure the progression of joint damage in this difficult-to-treat patient population. Results...
Source: HighBeam Research, Remicade.