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Starlix.
(nategilnide, Novartis)
An oral antidiabetic agent for use as monotherapy, with diet and exercise to improve glycemic control in people with type 2 diabetes. Also approved for use in combination with metformin (Glucophage) when that drug does not adequately control hyperglycemia.
* Dosage: 60-mg or 120-mg tablets taken 1-30 minutes before all three daily meals, skipping a dose when meals are skipped (120 mg recommended as the starting and maintenance dose; 60 mg can be used for people near their target Hp[A.sub.1c] when starting treatment).
* Special Considerations: No dose adjustments necessary for elderly. Use cautiously in people with chronic liver disease. Hypoglycemia a potential risk, but labeling says hypoglycemia was "relatively uncommon" in clinical trials. In monotherapy trials, 2.4% of 1,441 patients on Starlix had hypoglycemia, vs. 0.4% of 458 on placebo.
* Comment: Starlix, an amino acid derivative, stimulates pancreatic insulin secretion within 20 minutes of administration; plasma insulin levels peak after about 1 hour and drop to baseline after 4 hours. The drug "is ...
- FDA Approval for Starlix Received.
- Newspaper article from: Drug Week Henderson, CW January 19, 2001 700+ words
...treatment of type 2 diabetes. Starlix, a D-phenylalanine (amino...patients with type 2 diabetes. Starlix works by stimulating rapid...secretion. By this action, Starlix effectively lowers overall...Lawrence S. Phillips, MD, Emory University School of Medicine and nateglinide...
- FDA Approval for Starlix Received.(Novartis Pharmaceuticals Corp.)
- Newspaper article from: Biotech Week January 17, 2001 700+ words
...treatment of type 2 diabetes. Starlix, a D-phenylalanine (amino...patients with type 2 diabetes. Starlix works by stimulating rapid...secretion. By this action, Starlix effectively lowers overall...Lawrence S. Phillips, MD, Emory University School of Medicine and nateglinide...
- Novartis Receives FDA Approval For Starlix(R), A New Treatment for Type 2...
- Press release article from: PR Newswire December 22, 2000 700+ words
...alarming rate among Americans. Starlix, a D-phenylalanine (amino...patients with type 2 diabetes. Starlix works by stimulating rapid...secretion. By this action, Starlix effectively lowers overall...Endocrinology and Metabolism at Emory University School of Medicine. "Nateglinide...
- New Treatment for Type 2 Diabetes Gains FDA Approval.(Starlix)
- Newspaper article from: Drug Week Henderson, CW January 19, 2001 700+ words
...alarming rate among Americans. Starlix, a D-phenylalanine (amino...patients with type 2 diabetes. Starlix works by stimulating rapid...secretion. By this action, Starlix effectively lowers overall...Endocrinology and Metabolism at Emory University School of Medicine. "Nateglinide...
- New Treatment for Type 2 Diabetes Gains FDA Approval.(Novartis Pharmaceuticals'...
- Newspaper article from: Biotech Week January 17, 2001 700+ words
...alarming rate among Americans. Starlix, a D-phenylalanine (amino...patients with type 2 diabetes. Starlix works by stimulating rapid...secretion. By this action, Starlix effectively lowers overall...Endocrinology and Metabolism at Emory University School of Medicine. "Nateglinide...
- Starlix.(Brief Article)
- Magazine article from: Family Practice News Mechcatie, Elizabeth February 15, 2001 700+ words
...4% of 1,441 patients on Starlix had hypoglycemia, vs. 0...458 on placebo. * Comment: Starlix, an amino acid derivative...endocrinology and metabolism at Emory University, Atlanta. Approval was based...24 weeks. Monotherapy with Starlix led to significant reductions...
- Nateglinide (Starlix) showing promise as new antidiabetic agent.
- Newspaper article from: Drug Week October 3, 2003 700+ words
...Nateglinide (Starlix) is showing promise...Lawrence S. Phillips at Emory University and Beth E. Dunning...Practice (Nateglinide (Starlix): Update on a new...Endocrinology and Metabolism, Emory University School of Medicine...
- STARLIX (NATEGLINIDE) RESTORES NATURAL INSULIN SECRETION PATTERNS IN PATIENTS...
- Press release article from: PR Newswire September 19, 2000 700+ words
...increased mealtime flexibility - Jerusalem -- Starlix (nateglinide), an investigational stage...This fast-on, fast-off action of Starlix mimics the body's natural insulin secretion...The data from both studies showed that Starlix acts to normalise insulin secretion by...