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HILTON HEAD ISLAND, S.C. -- Tolterodine tartrate given at a dosage of 2 mg twice daily for the treatment of overactive bladder maintains its efficacy over a 2-year period and becomes more tolerable with time, according to the results of a study of more than 700 patients.
"The incidence of adverse effects actually decreased over 2 years, and only 1.1% of patients withdrew because of dry mouth," study investigator Dr. Harold Drutz said at the annual meeting of the American Urogynecologic Society.
Until now the long-term safety and efficacy of tolterodine (Detrol) has not been documented. The study showed that there was an average 22% drop in daily micturition episodes and an 81% drop in daily incontinence episodes after 1 year of treatment. Those improvements were maintained over the course of a second year of follow-up.
In addition, the incidence of side effects ...