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Tolterodine Safe, Effective When Taken Over a 2-Year Period.

OB GYN News

| February 01, 2001 | COPYRIGHT 2001 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

HILTON HEAD ISLAND, S.C. -- Tolterodine tartrate given at a dosage of 2 mg twice daily for the treatment of overactive bladder maintains its efficacy over a 2-year period and becomes more tolerable with time, according to the results of a study of more than 700 patients.

"The incidence of adverse effects actually decreased over 2 years, and only 1.1% of patients withdrew because of dry mouth," study investigator Dr. Harold Drutz said at the annual meeting of the American Urogynecologic Society.

Until now the long-term safety and efficacy of tolterodine (Detrol) has not been documented. The study showed that there was an average 22% drop in daily micturition episodes and an 81% drop in daily incontinence episodes after 1 year of treatment. Those improvements were maintained over the course of a second year of follow-up.

In addition, the incidence of side effects ...

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