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ORLANDO, FLA. -- Having a child cuts a woman's risk of unprovoked venous thromboembolism, according to results of an epidemiologic study with more than 19,000 women.
Compared with women who were never pregnant, women with a history of at least one pregnancy had a 41% reduced risk of venous thromboembolism (VTE) in a multivariate model that was adjusted for several potential confounders, Christiana Iyasere, M.D., told attendees during the annual meeting of the American College of Cardiology.
The difference in risk was statistically significant, said Dr. Iyasere, a cardiologist at Brigham and Women's Hospital in Boston.
The overall incidence of unprovoked VTE in nulliparous women was about 0.8%, compared with a rate of about 0.5% in women who had at least one pregnancy.
This means that, on average, a history of pregnancy cut the population risk for unprovoked VTE by about 3 cases per 1,000 people.
The study used data collected in the Women's Health Study, which recruited postmenopausal women in the health professions with a primary goal of assessing the safety and efficacy of both aspirin and vitamin E for the primary prevention of cardiovascular disease.
Dr. Iyasere and her associates used data collected by questionnaire from the nearly 40,000 women who participated in this study to evaluate the impact of endogenous hormones on VTE risk.
Source: HighBeam Research, Pregnancy history cuts risk of unprovoked VTE.(Obstetrics)