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Match the treatment to the condition.(LETTERS)(Letter to the Editor)
In his study of 87 women with localization-related epilepsy who charted their seizures in three menstrual cycles, Dr. Andrew G. Herzog astutely identified that 39% of the women "showed one of three predefined catamenial patterns" ("Look for Catamenial Epilepsy Pattern," March 1, 2005, p. 29).
However, Dr. Jose E. Cavazos failed to note that the treatment for catamenial epilepsy might by danazol to suppress the cycle.
A patient of mine reported grand mal epilepsy for 8 years, occurring every month within a few hours of the onset of menstruation. For years, she saw a host of neurologists and remained unresponsive to every antiseizure medication. When I treated her PMS and menstrual migraine, she became seizure free and has remained so for 22 years on 800 mg of danazol daily. Danazol, by suppressing the estrogen rise and fall in the luteal phase, may control these late cycle seizures by the same biochemical mechanism that I documented in the control of the most severe menstrual migraine (J. Reprod. Med. 1991;36:419-24).
By using clomiphene days 5-9, Dr. Cavazos may trigger a greater estrogen rise and subsequent fall and may potentially worsen the seizure disorder (similar to increasing estradiol in women with migraine).
Edward M. Lichten, M.D.
Del Mar, Calif.
Dr. Cavazos replies:
- Look for catamenial epilepsy pattern.(Gynecology)
- Magazine article from: OB GYN News March 1, 2005 700+ words
...according to Dr. Cavazos of...in women with catamenial epilepsy. Reported therapeutic...attempts to quell catamenial epilepsy via progesterone...side effects, Dr. Cavazos continued...etiologic factor in catamenial epilepsy is menstrual...
- Catamenial Epilepsy: In Search of a Clinical Entity and Its Prevalence.
- Magazine article from: Journal of Neuroscience Nursing Weatherford, Karen Joy December 1, 1999 700+ words
...Abstract: The prevalence of catamenial epilepsy has been difficult to...lack of a definition of catamenial epilepsy in previous studies...for future research on catamenial epilepsy has been proposed, and...
- CoCensys, Inc. Begins Epilepsy Study With Ganaxolone In Patients With...
- Press release article from: PR Newswire April 21, 1999 700+ words
...of ganaxolone in patients with catamenial epilepsy, a type of seizure that occurs...ganaxolone in women who demonstrate catamenial epilepsy, this open-label probe study...related seizures as well," Dr. Data said. CoCensys is a biopharmaceutical...
- Many epileptic women face sexual issues.(Neuropsychiatric Medicine)
- Magazine article from: Clinical Psychiatry News Sullivan, Michele G. September 1, 2007 700+ words
...experts say. Naturally, said Dr. Romila Mushtaq, an epileptologist...even thought to bring it up," Dr. Mushtaq said in an interview...force that seems to drive both catamenial epilepsy (a pattern of seizures that...PMDD) in this population. Dr. Andrew Herzog, a neurologist...
- IUD advocated for women using antiepileptics.(Gynecology)
- Magazine article from: OB GYN News Sullivan, Michele G. February 1, 2005 700+ words
...real data to back that up," Dr. Davis said. The contraceptive...contraceptive considerations, Dr. Davis said. Numerous studies...viable alternative. Women with catamenial epilepsy should use a form of birth control...reliably suppresses ovulation," Dr. Davis said. "This is an...
- Epileptic women need reliable contraceptives.(Women's Health)
- Magazine article from: Internal Medicine News Sullivan, Michele G. May 15, 2005 700+ words
...real data to back that up," Dr. Davis said. The contraceptive...contraceptive considerations, Dr. Davis said. Numerous studies...viable alternative. Women with catamenial epilepsy should use a form of birth control...reliably suppresses ovulation," Dr. Davis said. "This is an...
- Women and epilepsy: breakthrough seizures. (ask the doctor).(Brief Article)
- Magazine article from: The Exceptional Parent Harden, Cynthia L. June 1, 2002 700+ words
...she. Can you give us more information? Dr. Harden responds: Yes, you are correct...cycle. Catamenial seizures, also called catamenial epilepsy, occur in about one-third of all women...Cornell University in New York, NY. Dr. Harden is a member of several professional...
- Female Hormones Can Act As Powerful Tranquilizers
- Newspaper article from: The Washington Post Larry Thompson August 2, 1988 700+ words
...the Journal of Pharmacology and Experimental Therapeutics. Dr. Kelvin Gee, an assistant professor of pharmacology, found...menstrual cycle, including premenstrual syndrome (PMS) and catamenial epilepsy, a seizure disorder that affects some women during certain...
