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A surprising new study offers proof that heart attacks are caused by internal inflammation.
The November 14, 2002 issue of the New England Journal of Medicine reports that inflammation is the most powerful trigger of heart attacks, worse than cholesterol.
The article was based on a study that followed 28,000 women for eight years. Fully 77 percent of those who suffered heart attacks or strokes had cholesterol levels within the normal range--and 45 percent had levels in the ideal range.
"That means we're missing large numbers of individuals at risk," says Paul Ridker, MD, of Brigham and Women's Hospital in Boston.
The opportunity to which he refers is a blood test that measures something called C-reactive protein, or CRP, a measure of inflammation. The study found that the CRP test did a better job predicting heart-disease risk than cholesterol testing. Compared to patients with high cholesterol, those with high levels of inflammation were twice as likely to die from heart attacks and strokes.
Taken together, the CRP and cholesterol tests did ...