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Dance skin. (health matters).(fibulin-5 protein research)(Brief Article)
Researchers have discovered what appears to be a link between the lack of one critical protein and the development of wrinkles, sagging skin and serious age-related lung ailments like emphysema, which affects 1.8 million Americans.
The protein, called fibulin-5--or DANCE, for Developing Arteries and Neural Crest EGF-like--plays a big role in keeping skin elastic, say two recent studies conducted independently at two different medical schools. Fibulin-5, the studies discovered, helps develop "stretchy" fibers that keep blood vessels and organs healthy as we age.
The research, from independent studies at the University of California, San Diego, and the University of Texas Southwestern Medical Center in Dallas and reported in the January 10 issue of the British journal Nature, is tantalizing, if inconclusive. When fibulin-5 is missing, skin becomes wrinkled and sags, and blood vessels develop abnormally. When present, the protein appears to connect elastic fibers to their cells, ...
- The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex...
- Magazine article from: Journal of Medical Genetics Debeer, P. Schoenmakers, E.F.P.M. Twal, W.O. Argraves, W.S. Smet, L. De Fryns, J-P. Ven, W.J.M. Van de February 1, 2002 700+ words
...showed involvement of an alternatively spliced exon of the fibulin-1 gene (FBLN1 located in 22q13.3) and the Cl2orf2 (HoJ...Investigation of the possible functional involvement of the fibulin-1 protein (FBLN1) in the observed phenotype showed that...
- Protective role of fibulin-1 elucidated.
- Newspaper article from: Cancer Weekly June 1, 2004 700+ words
...NewsRx.com & NewsRx.net) -- The protective role of fibulin-1 (Fbln-1) in breast cancer patients has been elucidated...study in Oncogene (Immunological and pathobiological roles of fibulin-1 in breast cancer. Oncogene, 2004;23(12):2153...
- Scientists Report Regeneron's Angiopoietin-1 Can Protect Blood Vessels Against...
- Press release article from: Business Wire April 5, 2000 700+ words
...Medicine that Angiopoietin-1 protects blood vessels against damage and leak in preclinical...caused significant damage and leaking in blood vessels. Treatment with Angiopoietin-1 protected blood vessels against this damage and leak. Angiopoietin...
- Cancer survives via signals from nearby blood vessels long before new vessels...
- Newspaper article from: Health & Medicine Week January 12, 2004 700+ words
...growth-sustaining signals from nearby blood vessels telling them where to go for permanent...fledgling cancer cells long before new blood vessels have grown around the cancer to supply...cancer cells release signals to nearby blood vessels to stimulate new vessel growth, and...
- Obesity reversed in mice by destroying blood vessels that service fat cells.
- Newspaper article from: Biotech Week June 2, 2004 700+ words
...liposuction." The therapy destroys blood vessels supporting fat accumulation, causing...homes in on and promotes the death of blood vessels associated with white fat tissue...pioneered by Arap and Pasqualini. Blood vessels are not simply a uniform and ubiquitous...
- Spreading Cancer Survives Via Signals From Nearby Blood Vessels Long Before New...
- News wire article from: AScribe Medicine News Service December 18, 2003 700+ words
...growth-sustaining signals from nearby blood vessels telling them where to go for permanent...fledgling cancer cells long before new blood vessels have grown around the cancer to supply...cancer cells release signals to nearby blood vessels to stimulate new vessel growth, and...
- Prevent diabetes problems: Keep your heart and blood vessels healthy.(Pamphlet)
- Newspaper article from: Pamphlet by: National Institute of Diabetes & Digestive & Kidney Diseases May 15, 2000 700+ words
...parts of the body, such as the heart, blood vessels, and kidneys. Diabetes problems can be...day. Don't smoke. What do my heart and blood vessels do? Your heart and blood vessels make up your circulatory (SIR-kyoo...
- Researchers get stem cells to form blood vessels.
- Newspaper article from: Heart Disease Weekly January 11, 2004 700+ words
...differentiate into the cells that make up blood vessels and to actually form the vessels themselves...work will make possible the growth of blood vessels to repair the heart and other organs...in getting the stem cells to produce blood vessels only by using a series of steps, each...
- Bone Marrow Cells May Contribute to Growth of New Blood Vessels in Newborns.
- News wire article from: Ascribe Higher Education News Service August 30, 2002 700+ words
...rapidly, and they must develop new blood vessels fast enough to keep pace with that...blood contributes to the growth of new blood vessels during the neonatal period. The researchers...causes the immature cells to form new blood vessels at a faster rate. The findings are...
- Scientists Discover Key Role of Regeneron's Angiopoietins in Growth of New...
- Press release article from: Business Wire December 27, 1999 700+ words
...by promoting growth of new blood vessels in ischemic settings and repair...depends on an elaborate network of blood vessels to deliver nourishment and oxygen...its tissues. The failure of blood vessels can cause a wide range of serious...