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CDC: Avoid yellow fever vaccine in pregnancy. (May Cause Serious Adverse Events).
ATLANTA -- New yellow fever vaccine recommendations include updated information about vaccination of pregnant women.
The new statement, approved at a meeting of the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices, will replace the previous one issued in 1990. Since then, a serious adverse event--now known as viscerotropic disease--has been reported in association with yellow fever vaccination in seven people (six adults and one child), of whom six died.
The syndrome was previously called "febrile multiple organ system failure," said Dr. Martin S. Cetron of the CDC's National Center for Infectious Diseases.
Between 1980 and 2001, about 3 million doses of yellow fever vaccine were distributed to U.S. civilian vaccination centers, and 15 million doses went to the U.S. military Based on passive surveillance data, a crude estimate of the incidence of viscerotropic disease is 2.5/1 million vaccine doses distributed, Dr. Cetron said.
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