Good information: DATATRAK International helps researchers collect data. Its business and tech savvy help it collect revenue.(Weatherhead 100: #4 weatherhead: DATATRAK International)

Jeffrey A. Green is frustrated by the pharmaceutical industry's reluctance to change. "This industry is decades behind in advanced processes," says Green, president and CEO of DATATRAK International in Mayfield Heights.

The company creates electronic data capture technologies for use in clinical trials. "It replaces paper and three-ring binders used to collect information," Green says. "Instead, the data is on the Internet."

When the company was founded in the mid-1990s, potential customers at first were slow to change their ways. "When you're very successful and make a lot of money like the pharmaceutical industry does, you think you're doing everything …