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Ca metastases detected in frozen ovarian tissue.(Gynecology)
PHILADELPHIA -- Israeli researchers have detected microscopic cancer metastases in frozen ovarian tissue destined for transplantation.
The patient, a cancer survivor who had previously frozen her ovarian tissue for fertility preservation before chemotherapy, did not receive the transplant, but the case highlights the potential dangers of transplanting cryopreserved ovarian tissue, Dror Meirow, M.D., one of the investigators, said at the annual meeting of the American Society for Reproductive Medicine.
"We will continue to see significantly more cancer survivors. As awareness increases about the option of fertility preservation, and as these techniques become more successful, we highly recommend that ovarian tissue cryopreservation only be offered in centers where the best methods of cancer detection can be used," said Dr. Meirow of Sheba Medical Center in Tel-Hashomer, Israel.
The risk of ovarian metastasis in patients who have been treated for other cancers is very real, Dr. Meirow said. Ovarian metastasis is found in more than 11% of leukemia patients and is common in non-Hodgkin's lymphoma, but only rarely occurs in Hodgkin's disease. The incidence of metastasis varies in breast cancer patients depending on disease stage, and is unknown in patients with sarcomas.
Dr. Meirow's team routinely checks ovarian tissue after removal, and if cancer cells are detected, the tissue is not frozen.
They also reexamine previously frozen samples before transplant. This was the case in the canceled ...
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Source: HighBeam Research, Ca metastases detected in frozen ovarian tissue.(Gynecology)