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Study finds early cessation of magnesium is safe in preeclampsia.(Obstetrics)

OB GYN News

| December 01, 2004 | Moon, Mary Ann | COPYRIGHT 2004 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

WASHINGTON -- It appears to be safe to discontinue magnesium therapy for severe preeclampsia once diuresis is achieved, rather than maintaining the treatment for 24 hours after delivery, M. Todd Fontenot, M.D., reported.

Currently, there is no clearly defined end point for magnesium therapy, nor are there clinical parameters to indicate that the patient has recovered, and it would be safe to stop, said Dr. Fontenot of the Florida Perinatal Associates Fetal Therapy Program, St. Joseph's Women's Hospital, Tampa, Fla.

As many as 10%-30% of cases of eclampsia can develop post partum, and up to half of those develop at least 48 hours after delivery. The possibility of such late-onset eclampsia has led physicians to "customarily" continue magnesium therapy in preeclampsia for a full 24 hours after delivery, he noted at the annual meeting of the Central Association of Obstetricians and Gynecologists.

Dr. Fontenot and his associates conducted what he described as the first prospective randomized trial to determine whether onset of diuresis after delivery is a good clinical indicator that magnesium therapy could be stopped safely. Fifty women with preeclampsia received standard magnesium therapy for 24 hours after delivery, and 48 received it ...

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