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COPYRIGHT 2004 International Medical News Group
Palladone
(hydromorphone hydrochloride extended release, Purdue Pharma)
An extended-release formulation of the opioid agonist for managing persistent moderate to severe pain in patients requiring around-the-clock analgesia with a high-potency opioid for a prolonged time (generally weeks to months or longer). A schedule II controlled substance.
* Recommended Dosage: Given once every 24 hours; starting dose based on previous opioid dose and other factors. Capsules swallowed whole; should not be chewed, crushed, broken, or dissolved; that can increase absorption and possibly cause a fatal overdose, the label states.
* Special Considerations: Only for opioid-tolerant patients on opioid therapy, who require a minimum total daily opiate...
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