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Both valacyclovir and acyclovir were highly effective for suppressing the frequency and quantity of genital-herpes simplex virus shedding in a double-blind, three-period crossover study.
In 69 immunocompetent patients with genital HSV-2 who received, in random order, oral valacyclovir, acyclovir, and placebo, each for 7 weeks, there were no significant differences in frequency or quality of HSV shedding, as detected by polymerase chain reaction ...