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Maternal serum C-reactive protein levels associated with GDM risk.
2004 NOV 22 - (NewsRx.com & NewsRx.net) -- Higher maternal serum C-reactive protein levels are associated with higher risk of gestational diabetes, perinatologists in the U.S. have determined.
"Low-grade systemic inflammation is associated with an increased risk of type 2 diabetes mellitus. Limited available data suggest inflammatory factors are predictive of gestational diabetes (GDM), a condition that is biochemically similar to type 2 diabetes. We examined the association between C-reactive protein (CRP) and GDM risk," reported C.F. Qiu and colleagues, Swedish Medical Center, Seattle, Washington.
"Women were recruited before 16 weeks gestation and were followed until delivery. Maternal serum CRP (collected at 13 weeks' gestation, on average) was measured by a competitive immunoassay. We used generalized linear models to derive estimates of relative risks and 95% confidence intervals [CI]," the researchers said.
According to their report, "Approximately 4.5% of the cohort (38 of 851) developed GDM. Elevated CRP was positively associated with GDM risk (p for trend = 0.007). After adjusting for maternal prepregnancy body mass index (BMI), family history of type 2 diabetes, and nulliparity, women with CRP in the highest tertile experienced a 3.5-fold increased risk of GDM [95% CI 1.2, 9.8] as compared with those in the lowest tertile.
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