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Cystic hygroma prevalence underappreciated: Found in 1 in 300 pregnancies at 10-14 weeks. (Obstetrics).
NEW ORLEANS -- First-trimester cystic hygroma is considerably more common in the general population than has been appreciated, Dr. Fergal D. Malone said at the annual meeting of the Society for Maternal-Fetal Medicine.
This condition, which is characterized ultrasonographically by an enlarged hypoechoic space at the back of the fetal neck and visible septations, is present in approximately 1 in 300 pregnancies at 1014 weeks' gestation, according to the first prospective data analyzing its prevalence in an unselected population.
And unlike third-trimester cystic hygroma, first-trimester cystic hygroma is strongly associated with a range of structural and chromosomal abnormalities.
"The overall prognosis for this condition is poor," Dr. Malone said. "Fewer than one in four cases of first-trimester cystic hygroma will result in normal neonatal outcome. We hope these data, the first to demonstrate prevalence and natural history of this condition, will be helpful to you in counseling patients."
In a subanalysis from the First And Second Trimester Evaluation of Risk (FASTER) trial, in which thus far 26,966 patients have had ultrasound nuchal translucency screening, 81 cases of first-trimester cystic hygroma have been identified for a rate of 1 in 333 or 0.3%, said Dr. Malone of the division of maternal-fetal medicine, Columbia Presbyterian Medical Center, New York.
Previous estimates ranged from 1 in 1,000 to 1 in 12,000. Accurate knowledge about cystic hygroma has been hampered in the past by the fact that most data were collected from tertiary referral centers and do not reflect the wider population, he explained.
Among the 81 cases in this series, two were lost to follow-up. Of the remaining 79, ...
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Source: HighBeam Research, Cystic hygroma prevalence underappreciated: Found in 1 in 300...