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Glucose metabolism may link maternal obesity with NTDs.(Obstetrics)
VANCOUVER, B.C. -- As researchers struggle to understand the strong association between maternal obesity and neural tube defects, glucose metabolism is receiving increased scrutiny in studies, Gary Shaw, Ph.D., said during the annual meeting of the Teratology Society.
Studies have consistently shown that the rate of neural tube defects (NTDs) is about twofold higher among children born to obese mothers with an average body mass index (BMI) of about 30 kg/[m.sup.2], compared with children of normal-weight women, said Dr. Shaw, who is an epidemiologist with the California Birth Defects Monitoring Program in Berkeley.
It's not clear what factors may be associated with NTDs in these women.
Investigators have ruled out diabetes, gestational diabetes, a lack of folic acid or zinc intake, and ethnic distinctions. Higher NTD rates are seen among obese mothers, even in the absence of these factors.
Research suggesting a link between an increased intake of sweets in early pregnancy and a higher risk of NTDs, however, prompted Dr. Shaw to take a closer look at sugar intake.
In a study that included mothers of 454 children with an NTD and mothers of 462 normal controls, Dr. Shaw found that higher periconceptional intakes of sucrose and foods with higher glycemic index values--a measure of glucose metabolism--were associated with about a twofold increased risk of an NTD-affected pregnancy.
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Source: HighBeam Research, Glucose metabolism may link maternal obesity with NTDs.(Obstetrics)