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Ropivacaine may benefit preeclampsia, IUGR.(Obstetrics)
FORT MYERS, FLA. -- Epidural ropivacaine is showing promise for the treatment of preeclampsia and intrauterine growth restriction. Dr. Yehuda Ginosar said at the annual meeting of the Society for Obstetric Anesthesia and Perinatology.
In an ongoing randomized study of patients with both preeclampsia and intrauterine growth restriction, early results suggest antepartum chronic epidural therapy (ACET) with ropivacaine improves uteroplacental blood flow, which is impaired in both of these conditions. Treatment also appears to prolong pregnancy, said Dr. Ginosar of Hadassah Hebrew University Hospital, Jerusalem.
Of five patients at 22-32 weeks' gestation, three were randomized to receive ACET with ropivacaine and two served as controls. Optimal dosing was determined during the first 5 days of the study, with patients receiving either 0.04%, 0.06%, 0.08%, or 0.1% ropivacaine (or saline placebo) in random order.
A dose-response relationship between treatment and uteroplacental blood flow became apparent in the treatment group, ...
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...of Hong Kong (see also Anesthesia). The researchers concluded: "Despite historical evidence suggesting uteroplacental blood flow may be better maintained with ephedrine, the overall effect of the vasopressors on fetal oxygen supply and...
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...especially by reducing the chance of preeclampsia and placental abruption, but antihypertensives may decrease uteroplacental blood flow. Physicians should encourage women to control hypertension with prepregnancy weight loss, smoking cessation...
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...fetus. Nifedipine can cause maternal and fetal tachycardia, as well as hypotension in the mother and altered uteroplacental blood flow to the fetus. "There are no clear first-line drugs, so know your own tocolytic 'cocktail' well," said...
- Researchers from Hadassah University describe findings in preeclampsia.
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According to a study from Jerusalem, Israel, "No therapy is currently available to improve the reduced uteroplacental blood flow (UPBF) that characterizes pre-eclampsia. We hypothesized that sympathectomy induced by epidural local anaesthesia...
