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Breast ca mortality tied to age at diagnosis, stage.(News)
Women diagnosed with breast cancer before age 50, or at an advanced stage at any age, are more likely to die from that cancer than from any other cause of death, according to a study of more than 400,000 breast cancer patients.
Black women and women with estrogen receptor-negative tumors also face a greater risk of dying from their cancers, said Catherine Schairer, Ph.D., of the National Cancer Institute, Bethesda, Md., and her associates (J. Natl. Cancer Inst. 96[17]:1311-21, 2004).
The study, the first comprehensive risk analysis of death from breast cancer, compared with other causes, points up the importance of early diagnosis and increasing access to aggressive therapy for black women. The results should also help physicians weigh the risks and benefits of aggressively treating older women, the investigators said.
"Our data suggest that death from breast cancer remains a substantial concern, particularly within 5 years after diagnosis, even among older women. These statistics may be particularly relevant in weighing the use of adjuvant chemotherapy in elderly women," Dr. Schairer and her associates said.
The higher probability of death in black women may be attributable to lack of access to care and the higher prevalence of obesity and its associated comorbidities.
The study analyzed all causes of death during up to 28 years of follow-up in more than 400,000 breast cancer patients (395,251 white and 35,259 black) diagnosed from 1973 to 2000. The data, extracted from the Surveillance, Epidemiology, and End Results (SEER) program, were broken down by age at diagnosis, race, and tumor staging. The report also included a risk analysis of death depending on tumor size and estrogen-receptor status.
Overall, white women had a slightly lower probability of dying from their cancers by the end of the study period than black women. For both white and black ...
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Source: HighBeam Research, Breast ca mortality tied to age at diagnosis, stage.(News)