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BV follow-up at 3 months; Single-dose metronidazole: 65% clinical cure rate.(News)
SAN DIEGO -- A single, 2-g dose of metronidazole given orally for the treatment of bacterial vaginosis resulted in a clinical cure rate of 65% and a therapeutic cure rate of 25% at 3 months, results from the largest study of its kind have shown.
"The data about long-term outcomes in women with bacterial vaginosis treated with single-dose metronidazole are very limited," Dr. Harold C. Wiesenfeld said at the annual meeting of the Infectious Diseases Society for Obstetrics and Gynecology. "There are no long-term studies, [and] all of the published treatment trials to date involved no more than 100 women."
Recommended treatment for bacterial vaginosis (BV) includes both oral and topical metronidazole and clindamycin. "Unfortunately, these regimens are far from ideal, with up to a 40% failure rate 1 month following treatment." Dr. Wiesenfeld said.
He and his associates conducted an observational cohort study of women who presented with pelvic infections at ambulatory sites in Pittsburgh during 1998-2000. Inclusion criteria included women aged 15-30 years who met at least three out of four Amsel criteria for BV. Exclusion criteria included pregnancy, recent antibiotic use, recent gynecologic surgery, having an IUD, or women whose first follow-up was more than 6 months from enrollment.
All women underwent pelvic exam, microbiologic tests of vaginal fluid, and cervical swabs for Chlamydia trachomatis and Neisseria gonorrhoeae. All took a single, 2-g dose of metronidazole, for BV, plus a 1-g dose of azithromycin and a 400-mg dose of cefixime, for empiric treatment of cervicitis. A follow-up evaluation was conducted a mean of 15 weeks after treatment in ...
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...20% of women with BV in studies that use Amsel criteria to define clinical failure. "As clinicians...study. A total of 115 participants achieved a clinical cure according to Amsel criteria at some point in the study. At week 16, an...
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...20% of women with BV in studies that use Amsel criteria to define clinical failure. "As clinicians...study. A total of 115 participants achieved a clinical cure according to Amsel criteria at some point in the study. At week 16, an...
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...volatilizable amines. Combined with the evaluation of the vaginal discharge, these tests provide three of the four clinical, or Amsel, criteria necessary for the evaluation of bacterial vaginosis. Test results are read within 2 minutes as a plus (+) or minus...
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...any clinic visit. HIV-positive patients were excluded. Diagnosis of BV was based on the presence of three out of four Amsel criteria. Participants with BV were treated with oral metronidazole, Ms. Brotman said. Counseling and treatment of adolescents...
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...any clinic visit, HIV-positive patients were excluded. Diagnosis of BV was based on the presence of three out of four Amsel criteria. Participants with BV were treated with oral metronidazole, Ms. Brotman said. Counseling and treatment of adolescents...
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...clinics in Pittsburgh and Seattle. Participants were aged 14-45 years. All patients had severe BV, defined by clinical Amsel criteria and a Nugent's score of at least 4. "These were 'hard-core' bacterial vaginosis women," said Dr. Marrazzo of...
Source: HighBeam Research, BV follow-up at 3 months; Single-dose metronidazole: 65% clinical...