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Nurses' Health Study: moderate drinking may preserve cognitive function in elderly.(Clinical Rounds)
SAN FRANCISCO -- Light to moderate alcohol consumption by elderly women is associated with improved cognitive function, compared with that of nondrinkers, according to new data from the landmark Nurses' Health Study.
This relationship between alcohol intake and cognitive function appears to be causal, as is thought by many to also be true for the apparent protective effect of moderate alcohol consumption on cardiovascular risk, which has been far more extensively studied, Dr. Francine Grodstein said at the annual meeting of the American Academy of Neurology.
The association between moderate alcohol intake and better cognitive function held up in multivariate analyses adjusted for numerous variables, including a vitality index that accounted for drinking-related aspects of personality as well as social contact and general health, said Dr. Grodstein of the Harvard School of Public Health, Boston.
Moreover, it's highly unlikely that there will ever be a randomized clinical trial assigning women to drink alcohol or abstain. So these observational data from the Nurses' Health Study may be about as close to definitive regarding alcohol's relationship to cognitive function as physicians and patients are likely to see, she said.
The Nurses' Health Study is a prospective National Institutes of Health-sponsored study involving nearly 122,000 nurses who were aged 30-55 years when the study began in 1976.
The cognitive substudy involves more than 19,000 community-dwelling women who were aged 70-81 during 1995-2001, when they began taking a battery of cognitive-function tests over the telephone repeated at 2-year intervals. To be eligible for participation, women couldn't consume more than 30 g of alcohol per day (the equivalent of three standard drinks), be on antidepressant medication, have a history of stroke at baseline, or report a substantial change in their alcohol intake.
That left 12,480 elderly women for whom reliable alcohol intake information was available from a highly detailed and well-validated food frequency questionnaire completed periodically by all participants in the Nurses' Health Study. Of those, 44% consumed an average ...
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