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Breast Ca survivors: PET scan imaging depicts 'chemobrain'.(Gynecology)
PHILADELPHIA -- PET imaging reveals decreased resting metabolism in certain brain regions of breast cancer survivors treated with adjuvant chemotherapy, and the severity correlated with the severity of cognitive impairments in these women, Dr. Daniel H. Silverman, Ph.D., said at the annual meeting of the Society of Nuclear Medicine.
Over the years, persistent cognitive impairment has been documented in a number of women who have undergone chemotherapy for breast cancer. The condition is known as "chemobrain."
"These are usually women who have complex jobs and complain that they no longer can multitask the way that they used to do or keep things in their heads as well as they used to," said Dr. Silverman of the University of California, Los Angeles.
He and his colleagues used functional imaging to assess regional brain metabolism and blood flow in 16 women who had adjuvant chemotherapy, 8 women who had breast cancer but did not undergo chemotherapy, and 10 healthy women with no history of breast cancer or chemotherapy. Both groups of cancer survivors underwent resting fluorodeoxyglucose (FDG)-PET scans to assess brain metabolism and oxygen 15-water activation scans to assess cerebral blood flow during memory-related tasks.
Women in the chemotherapy group had decreased glucose metabolism in the ...
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Source: HighBeam Research, Breast Ca survivors: PET scan imaging depicts...