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Expert opinion: metformin first-line therapy in some patients with PCOS.(Gynecology)

OB GYN News

| September 01, 2004 | MacReady, Norra | COPYRIGHT 2004 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

LAS VEGAS -- Metformin may be a good first-line therapy for inducing ovulation in selected patients with polycystic ovary syndrome, Dr. Rogerio Lobo said at the Fifth World Congress on Controversies in Obstetrics, Gynecology, and Infertility.

Candidates for treatment with metformin are women who want to conceive and have polycystic ovary syndrome (PCOS) and a history of miscarriage or clomiphene resistance. Women who are obese and have metabolic syndrome may also benefit from metformin therapy, regardless of whether they are trying to conceive, said Dr. Lobo, professor of obstetrics and gynecology at Columbia University, New York.

Among 543 patients with PCOS included in a recent metaanalysis of 13 studies, the odds ratio of achieving ovulation with metformin versus a placebo was 3.88. When the metformin plus clomiphene was compared ...

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