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Lymphoreticular tissues play role in intestinal IgA immunity.
2004 SEP 22 - (NewsRx.com & NewsRx.net) -- Gut-associated lymphoreticular tissues play a role in antigen-specific intestinal IgA immunity.
According to a study from Japan, Korea, and the United States, "This study assessed the roles of the postnatal lymphotoxin-beta receptor (LTbetaR)-mediated signals in the gut-associated lymphoreticular tissues of mice for subsequent regulation of antigen-specific intestinal IgA responses. Blockade of LTbetaR-dependent events by postnatal administration of the fusion protein of LTbetaR and IgG Fc (LTbetaR-Ig) reduced both the size and numbers of Peyer's patches (PP) without influencing the PP micro-architecture. Interestingly, inhibition of LTbetaR-dependent signaling revealed significant reductions in the formation of follicular dendritic cell clusters in mesenteric lymph nodes (MLN)."
"Furthermore, these postnatal signaling events controlled the development of isolated lymphoid follicles (ILF) because treatment with LTbetaR-Ig eliminated the formation of ILF," stated Masafumi Yamamoto at Nihon University and collaborators in Japan, Korea, and the United States. "LTbetaR-Ig-treated mice with altered micro-architecture of MLN and lacking ILF were still able to produce significant antigen-specific mucosal IgA responses after oral immunization; however, the levels were significantly lower than those seen in control mice. These results imply the importance of ILF for ...
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Source: HighBeam Research, Lymphoreticular tissues play role in intestinal IgA immunity.