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Lymphoreticular tissues play role in intestinal IgA immunity.
2004 SEP 22 - (NewsRx.com & NewsRx.net) -- Gut-associated lymphoreticular tissues play a role in antigen-specific intestinal IgA immunity.
According to a study from Japan, Korea, and the United States, "This study assessed the roles of the postnatal lymphotoxin-beta receptor (LTbetaR)-mediated signals in the gut-associated lymphoreticular tissues of mice for subsequent regulation of antigen-specific intestinal IgA responses. Blockade of LTbetaR-dependent events by postnatal administration of the fusion protein of LTbetaR and IgG Fc (LTbetaR-Ig) reduced both the size and numbers of Peyer's patches (PP) without influencing the PP micro-architecture. Interestingly, inhibition of LTbetaR-dependent signaling revealed significant reductions in the formation of follicular dendritic cell clusters in mesenteric lymph nodes (MLN)."
"Furthermore, these postnatal signaling events controlled the development of isolated lymphoid follicles (ILF) because treatment with LTbetaR-Ig eliminated the formation of ILF," stated Masafumi Yamamoto at Nihon University and collaborators in Japan, Korea, and the United States. "LTbetaR-Ig-treated mice with altered micro-architecture of MLN and lacking ILF were still able to produce significant antigen-specific mucosal IgA responses after oral immunization; however, the levels were significantly lower than those seen in control mice. These results imply the importance of ILF for ...
- Lymphoreticular tissues play role in intestinal IgA immunity.
- Newspaper article from: Obesity, Fitness & Wellness Week September 25, 2004 700+ words
...role in antigen-specific intestinal IgA immunity. According to...lymphotoxin-beta receptor (LTbetaR)-mediated signals in...regulation of antigen-specific intestinal IgA responses. Blockade of LTbetaR-dependent events by postnatal...
- Intestinal IgA is not enough to control parasitic infection; IL-6 is required.
- Newspaper article from: Immunotherapy Weekly April 30, 2003 700+ words
2003 APR 30 - (NewsRx.com & NewsRx.net) -- Intestinal IgA against Giardia lamblia is not enough to control parasitic infection, IL-6 is required. According to recent research from Switzerland...
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- Newspaper article from: Biotech Week May 26, 2004 700+ words
...The lymphotoxin-beta receptor (LTbetaR) pathway is critical for maintenance...To investigate the mechanisms by which LTbetaR activation contributes to the pathology of chronic inflammation we used a soluble LTbetaR-Ig fusion protein as a competitive inhibitor...
- Lymphotoxin beta receptor plays key role in infection control.
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...Regensburg. The lymphotoxin beta receptor (LTbetaR) also mediates immune control of Mycobacterium...the report. Granuloma macrophages from LTbetaR-deficient mice demonstrated impaired...in wild-type and knockout animals. LTbetaR-deficient mice were also "dramatically...
- LT beta R is essential for proper thymic function and autoimmune control.
- Newspaper article from: Proteomics Weekly November 10, 2003 700+ words
...epithelial cells (MECs) communicate via the lymphotoxin beta receptor (LTbetaR) signaling axis. Normal differentiation of thymic MECs requires LTbetaR ligand on thymocytes and LTbetaR together with NF-kappabeta-inducing kinase (Nik) in thymic...
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- Newspaper article from: Immunotherapy Weekly September 1, 2004 700+ words
...intestinal infection is associated with the presence of intestinal IgA antibodies against the parasite's galactose-inhibitable...that in linear or cyclized form were recognized by pooled intestinal IgA antibodies and serum IgG antibodies from subjects with ALA...
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- Press release article from: PR Newswire May 5, 1998 700+ words
...specific INF-y responses, along with the production of local intestinal IgA antibodies directed against Campylobacter, were the strongest...volunteers protected against illness had increased INF-y and intestinal IgA antibody responses, in contrast to only 28% and 24...
- Lymphotoxin beta receptor is involved in gut autoimmunity, inflammation, IgA.
- Newspaper article from: Immunotherapy Weekly November 19, 2003 700+ words
...Signaling through lymphotoxin beta receptor (LTbetaR) initiates the unfolding of a host of...IgA) production, it was uncovered that LTbetaR signaling in the lamina propria (LP...intestinal inflammation via the ligands for LTbetaR," wrote R. Chin and coworkers at the...