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High-dose estrogen-progestin Tx stops DUB in adolescents; small study.(Gynecology)
PHILADELPHIA -- Treatment with a high dose of estrogen plus progestin stopped dysfunctional uterine bleeding in a high proportion of adolescent girls with this disorder in a single-center study of 34 patients.
No patient required dilatation and curettage, suggesting that the regimen compared well with a high-dose, intravenous regimen of estrogen only, Dr. Saara Schwartz said at a poster presentation at the annual meeting of the North American Society for Pediatric and Adolescent Gynecology.
The high-dose oral regimen of estrogen plus progestin was markedly more effective at stopping bleeding in girls who were diagnosed with dysfunctional uterine bleeding (DUB) than in those whose uterine bleeding was from a different cause.
Many girls who have uterine bleeding are treated empirically, so patients who do not stop bleeding after 72 hours of treatment with the high-dose, estrogen plus progestin regimen should be assessed for a diagnosis other than DUB, said Dr. Schwartz, a physician specializing in adolescent medicine at Schneider Children's Hospital in New Hyde Park, N.Y.
Dr. Schwartz reviewed the case records of all adolescents (aged 12-20 years) who were admitted to the children's hospital with abnormal uterine bleeding during 1991-2001. A diagnosis of DUB was made in 18 (53%) of the ...
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Source: HighBeam Research, High-dose estrogen-progestin Tx stops DUB in adolescents; small...