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NK4 suppresses liver metastasis in murine colon cancer models.

Gastroenterology Week

| August 23, 2004 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 AUG 23 - (NewsRx.com & NewsRx.net) -- NK4 suppresses liver metastasis in murine colon cancer models.

According to a study from Japan, "hepatocyte growth factor (HGF) is involved in malignant behavior of cancer cells by enhancing invasion and metastasis. We earlier found that NK4, a four-kringle fragment of HGF, functions as both an HGF antagonist and an angiogenesis inhibitor. We have now carried out studies to determine if hydrodynamics-based delivery and expression of the NK4 gene would inhibit liver metastasis and invasive growth of colon carcinoma cells in mice."

"When the naked plasmid for NK4 was introduced into mice by hydrodynamics-based gene…

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Source: HighBeam Research, NK4 suppresses liver metastasis in murine colon cancer models.

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