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NK4 gene transfer stops the dissemination of gallbladder cancer.

Cancer Gene Therapy Week

| August 23, 2004 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 AUG 23 - (NewsRx.com & NewsRx.net) -- NK4 gene transfer stops the dissemination of gallbladder cancer.

According to a study from Japan, "gallbladder cancer cells are stimulated by hepatocyte growth factor (HGF) in vitro and in vivo. We constructed an adenovirus vector, AdCMV.NK4, carrying the HGF antagonist HGF/NK4 (NK4) and evaluated whether or not this vector can suppress the peritoneal implantation of gallbladder cancer in a novel peritoneal injury mouse model."

"A human gallbladder cancer cell line (GB-d1) and human peritoneal mesothelial cells infected with the adenovirus vector produced a substantial level of NK4 protein. An invasion of GB-d1 cells…

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Source: HighBeam Research, NK4 gene transfer stops the dissemination of gallbladder cancer.

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