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Intrinsic dysregulation of elastic fibers: genes, not weight, key to striae gravidarum.(Obstetrics)

OB GYN News

| August 01, 2004 | Evans, Jeff | COPYRIGHT 2004 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

PROVIDENCE, R. I. -- Genetic factors appear to play a role in the development of striae gravidarum, rather than prepregnancy weight or increases in weight during pregnancy, Dr. Anne Chang said at the annual meeting of the Society for Investigative Dermatology.

Dr. Chang and her associates surveyed a group of 161 women who had given birth and found that 55% had striae gravidarum (SG), which arose on average at a gestational age of 25 weeks. Ninety percent of the women who reported having SG said that they developed them during their first pregnancy, while 10% said that SG first developed during their second pregnancy.

Women were significantly more likely to develop SG if their mother or other family members had SG, if they had a personal history of breast or thigh striae, or if they were nonwhite.

A reorganization of and a decrease in the elastic network of skin histologically characterize SG. The genetic risk factors identified in the study suggest that an intrinsic dysregulation of elastic ...

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