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Cytogenetic profiles: genetics can triage management of recurrent miscarriage.(Obstetrics)
RANCHO MIRAGE, CALIF. -- A series of studies has helped to shed light on when cytogenetic profiles and preimplantation genetic diagnosis should be ordered for women with recurrent miscarriages.
Cytogenetic abnormalities account for recurrent miscarriages in only about half of patients, but an initial genetic study of the products of conception can help direct management of care for these women, Dr. Mary Stephenson, professor of obstetrics and gynecology at the University of Chicago, said at the annual meeting of the Pacific Coast Reproductive Society.
Cytogenetics profiles are recommended in the following cases:
* After a second consecutive miscarriage and all subsequent miscarriages at less than 10 weeks' gestation.
* After all unexplained pregnancy losses at more than 10 weeks' gestation.
* After all miscarriages following infertility treatments, such as in vitro fertilization.
In a study of 420 specimens from 285 patients who had had recurrent miscarriages, Dr. Stephenson and her associates at her former institution, the University of British Columbia in Vancouver, found that successful cytogenetic analysis was far more likely after D & C than when the products of conception were submitted following expectant management of a miscarriage.
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