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Future screening tool? Maternal IL-6 may predict intrapartum fever.(Obstetrics)
FORT MYERS, FLA. -- Maternal serum interleukin-6 levels before labor and duration of epidural analgesia each were significantly associated with intrapartum fever in a recent study.
The findings suggest that both underlying maternal inflammation and intrapartum factors play a part in fever development, Dr. Laura Goetzl reported at the annual meeting of the Society for Obstetric Anesthesia and Perinatology.
Of 52 nulliparous women at term but not yet in labor who were enrolled in the prospective cohort study, 83% received epidural analgesia. Of those, 13% developed intrapartum fever higher than 100.4[degrees] F, said Dr. Goetzl of Baylor College of Medicine, Houston.
After ethnicity and duration of exposure to epidural analgesia were controlled for, prelabor IL-6 levels predicted 50% of intrapartum fever.
Of the 10 women who had IL-6 levels greater than 3.0 pg/mL, 7 received epidural analgesia. Of the three who did not, none developed fever. For those who did receive an epidural, its duration was significantly shorter in those who remained afebrile (191.5 minutes vs. 479 minutes).
In the women without elevated IL-6 levels, there was no correlation between epidural analgesia and fever development.
Hispanic women had higher IL-6 levels than non-Hispanic women (median of 2.11 vs. 1.12 pg/mL), which ...
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Source: HighBeam Research, Future screening tool? Maternal IL-6 may predict intrapartum...