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Botox eased chronic pelvic pain in pilot study: levator ani spasms.(Gynecology)
LAS VEGAS -- Promising results from a pilot study may lead to a role for botulinum toxin in relieving certain kinds of chronic pelvic pain, Dr. Sherin Jarvis said at the annual meeting of the American Association of Gynecologic Laparoscopists.
Twelve women with pelvic floor muscle spasms and at least a 2-year history of undergoing multiple treatments for chronic pelvic pain were treated with injections of botulinum toxin type A (Botox) in the levator ani muscles. Investigators administered bilateral injections totalling 40 units of Botox in one of three different dilutions into the puborectalis and pubococcygeus muscles of patients under conscious sedation.
One patient withdrew from the 12-week study in the final week. Overall, visual analog scale scores for dyspareunia and dysmenorrhea improved significantly. Non-significant trends toward improvements in nonmenstrual pain and dyschesia also were seen, said Dr. Jarvis of the University of New South Wales, Sydney, Australia.
At baseline, all patients had hypertonicity of the pelvic floor muscles, which was confirmed by manometry. "In theory, this is normal muscle that behaves abnormally," causing spasms and pain, she said. Repeat manometry 4 weeks after ...
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