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Warning about treating DCIS without radiation: high recurrence rate.(News)
SAN ANTONIO -- Treatment of even the smallest low-grade ductal carcinoma in situ with wide excision alone, omitting radiotherapy, results in an unacceptable recurrence rate, Dr. Jennifer S. Wong reported at a breast cancer symposium sponsored by the Cancer Therapy and Research Center.
How to best manage ductal carcinoma in situ (DCIS) has become a hot topic in oncology. Widespread mammographic screening has produced an explosion of breast cancer diagnoses involving very small, non-palpable, low-grade DCIS.
It has long been known that radiotherapy following excision of DCIS reduces the local recurrence rate by 60%, compared with surgery alone, but it is time consuming, inconvenient, costly, and involves some toxicity. The hypothesis that many small, carefully selected DCIS lesions could effectively be treated with wide excision alone has therefore enjoyed widespread popularity fueled by several favorable retrospective case series.
Dr. Wong and her coinvestigators at Dana-Farber/Harvard Cancer Center, Boston, decided to conduct a planned 200-patient prospective study that they expected would confirm this notion. But they had to halt the study after 158 patients because of a high local recurrence rate.
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Source: HighBeam Research, Warning about treating DCIS without radiation: high recurrence...