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Bupropion appears safe in pregnant women: not linked to increase in major fetal dejects: first study in pregnancy.(News)
PHILADELPHIA -- Bupropion does not appear to increase the risk for major fetal malformation and seems effective in decreasing smoking in pregnant women, according to interim results of an ongoing trial.
"There is always a question of benefits and risks when taking a drug during pregnancy. However, with our interim study results, a doctor can now know that the drug is probably not associated with malformations," said Brian Chan, who is a researcher with the Motherisk program at the Hospital for Sick Children in Toronto.
The Motherisk study is the first on the use of bupropion during pregnancy, Mr. Chan said at the annual meeting of the Teratology Society.
In the prospective, observational, controlled study, 101 women are enrolled for bupropion treatment (either for smoking cessation or depression) and 100 are enrolled as controls. To date, mean birth weight, gestational age at time of delivery, and rates of birth defects, miscarriages, and therapeutic abortions were not significantly different between the two groups.
In the treatment group, pregnancy outcomes are available for 99 women (69 for antidepressant use and 30 for smoking cessation), and two pregnancies are still pending. There were 73 live births with no birth defects, 18 miscarriages, ...
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Source: HighBeam Research, Bupropion appears safe in pregnant women: not linked to increase in...