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Drop in HDL cholesterol seen after childbirth.(10-Year Follow-Up Study)
MIAMI BEACH -- Childbearing was associated with a significant decrease in HDL cholesterol levels in a 10-year follow-up study of almost 2,000 black and white women.
A first birth was associated with a persistent decline in HDL cholesterol to the same degree in women of both races. The declines were not primarily mediated by weight gain, central adiposity, or changes in behavior associated with childbearing, said Erica P. Gunderson, Ph.D.
"We might propose that changes in endocrine milieu, insulin resistance, or other factors of body fat distribution after a first birth may affect HDL cholesterol levels in women of reproductive age," she said at a conference on cardiovascular disease epidemiology and prevention sponsored by the American Heart Association.
Cross-sectional studies have demonstrated an inverse association between HDL cholesterol and parity or gravidity, but there are few long-term prospective studies exploring this association, according to Dr. Gunderson, an epidemiologist with the Kaiser Permanente Foundation, Oakland, Calif.
Besides parity, Dr. Gunderson and her colleagues evaluated whether race plays a role in lipid changes from pregnancy. They began with a biracial sample of 2,787 women participating in the Coronary Artery Disease Risk Development in Young Adults (CARDIA) study. Participants were between 18 and 30 years old at enrollment in the 1980s.
Women were excluded from the study if they were pregnant or breast-feeding at baseline, had undergone a hysterectomy, or had both ovaries removed. To be included, the patient had to attend at least one follow-up exam during years 5, 7, or 10 so changes in LDL, HDL, total cholesterol, and triglycerides could be assessed. ...
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