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Postprocedure use of GnRH agonist doesn't boost UAE.(Study Of 26 Patients)
SCOTTSDALE, ARIZ. -- Postprocedure use of a GnRH agonist did not enhance the effects of uterine artery embolization in the treatment of fibroids in a small prospective, randomized trial.
Given these results, physicians should pick one treatment or the other but should not bother combining them, study investigator Dr. George A. Vilos said at an international congress on uterine fibroids sponsored by the American Association of Gynecologic Laparoscopists.
It's well known that GnRH agonists temporarily shrink uterine fibroids by about 50% after 3 months of treatment, and that fibroids grow back within a few months once the drug is stopped.
Uterine artery embolization (UAE) has been shown to permanently shrink fibroids by about 50%.
Investigators wondered whether combining the two treatments might make a fibroid completely disappear, at least temporarily.
In the study, 26 women with symptomatic uterine fibroids underwent UAE with polyvinyl alcohol particles as the primary embolic agent. Fourteen randomly chosen patients received 10.8 mg of the GnRH agonist goserelin injected 24 hours after the ...
- Low-dose mifepristone matches GnRH agonists for uterine fibroids.(Six Small...
- Magazine article from: OB GYN News August 1, 2003 700+ words
...therapy for uterine fibroids, in a total...congress on uterine fibroids sponsored by...must limit GnRH agonist therapy to...treatment of uterine fibroids. Two studies...mifepristone and a GnRH agonist and four were...
- Pretreatment with drug therapy eases and improves surgery for uterine fibroids.
- Press release article from: PR Newswire November 12, 1990 700+ words
...IMPROVES SURGERY FOR UTERINE FIBROIDS GENEVA, Switzerland...releasing hormone (GnRH) agonist, Zoladex effectively...reproductive years. Uterine fibroids are estimated to...hysterectomies annually. Uterine fibroids are discrete tumor...
- Zonagen Reports Interim Assessment of One Month Data from Study of Progenta in...
- Press release article from: Business Wire November 8, 2004 700+ words
...TM) in the treatment of uterine fibroids. The study included three...control was Lucrin(R), a GnRH agonist, commonly used for the treatment...of 30 women diagnosed with uterine fibroids. The last day of dosing for...
- GnRH agonist treats empty follicle syndrome by triggering hormone surges.
- Newspaper article from: Drug Week November 21, 2003 700+ words
...NewsRx.com & NewsRx.net) -- GnRH agonist treats empty follicle syndrome by triggering...in gonadotropin-releasing hormone (GnRH) agonist down-regulated in vitro fertilization...observed in both GnRH antagonist and GnRH agonist down-regulated IVF cycles when final...
- GnRH agonist does not increase cardiovascular mortality.(Urology)
- Magazine article from: Internal Medicine News Boschert, Sherry August 1, 2008 700+ words
...64% of 468 patients received salvage GnRH agonist therapy for a median of 3 years after...radiotherapy-only group who received salvage GnRH agonist therapy, or when applying alternative...increased cardiovascular mortality. GnRH agonist therapy has been shown to decrease the...
- GnRH Agonist Regimen May Reduce Breast Cancer Risk.
- Magazine article from: OB GYN News JANCIN, BRUCE February 15, 2001 700+ words
SAN ANTONIO -- A GnRH agonist-based hormonal chemo-prevention...nasal spray containing 1 mg of the GnRH agonist deslorelin self-administered each...specifically, this dose of the GnRH agonist is intended to induce a reversible...
- Enhanced MR-Guided Focused Ultrasound (MRgFUS) Guidelines Demonstrate Improved...
- Press release article from: Business Wire May 9, 2007 700+ words
...Prevalence and Clinical Burden of Uterine Fibroids, Cost and Adverse Events for Traditional...non-invasively treat symptomatic uterine fibroids. "These findings further underscore...the millions of women suffering from uterine fibroids," said Dr. Gee. "With these expanded...
- The National Uterine Fibroids Foundation Announces 'Opening Doors,' the First...
- Press release article from: PR Newswire December 30, 2002 700+ words
...Monterey, California by the National Uterine Fibroids Foundation. Designed primarily for women with uterine fibroids, this event will take place the...care and treatment of women with uterine fibroids are also invited to participate...