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Weekly, daily risedronate equally effective. ('A Reasonable Alternative').
SAN DIEGO -- A 35-mg weekly dose of risedronate is just as effective as a 5-mg daily dose, according to results of a detailed bone study.
The findings suggest that weekly dosing of the agent for postmenopausal women "is a reasonable alternative" to daily dosing, Earl W. Sod, Ph.D., reported in a poster session at the annual meeting of the American Association of Clinical Endocrinologists.
"From a bone safety point of view, the weekly-dose group had results similar to the daily-dose group in general across all parameters. The findings were remarkably close to what we expected for the study."
He added that this is the first study to demonstrate that daily and weekly regimens of risedronate (Actonel) produce similar results at the bone tissue and cellular levels.
The investigators assessed the lumbar spine bone mineral density and obtained iliac crest biopsy specimens in 109 postmenopausal women on risedronate therapy at baseline and at the end of 2 years. The dosing of the 109 patients was as follows: 40 received 5 mg daily; 37 ...
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...comparable to the 4.0 percent increase achieved with the 5 mg daily dose. Total hip, femoral neck and trochanteric BMD also increased...profile of risedronate 35 mg once a week was comparable to the 5 mg daily dose. The study included postmenopausal women at least 50...
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Source: HighBeam Research, Weekly, daily risedronate equally effective. ('A Reasonable...