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Weekly, daily risedronate equally effective. ('A Reasonable Alternative').

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| July 01, 2003 | Brunk, Doug | COPYRIGHT 2003 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

SAN DIEGO -- A 35-mg weekly dose of risedronate is just as effective as a 5-mg daily dose, according to results of a detailed bone study.

The findings suggest that weekly dosing of the agent for postmenopausal women "is a reasonable alternative" to daily dosing, Earl W. Sod, Ph.D., reported in a poster session at the annual meeting of the American Association of Clinical Endocrinologists.

"From a bone safety point of view, the weekly-dose group had results similar to the daily-dose group in general across all parameters. The findings were remarkably close to what we expected for the study."

He added that this is the first study to demonstrate that daily and weekly regimens of risedronate (Actonel) produce similar results at the bone tissue and cellular levels.

The investigators assessed the lumbar spine bone mineral density and obtained iliac crest biopsy specimens in 109 postmenopausal women on risedronate therapy at baseline and at the end of 2 years. The dosing of the 109 patients was as follows: 40 received 5 mg daily; 37 ...

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