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Ondansetron relieves pruritus linked to spinal opioids. (Cost a Major Drawback).
PHOENIX,. ARIZ. -- Ondansetron has a dose-related prophylactic effect in relieving pruritus associated with spinal opioids administered for labor analgesia, Dr. Scott Segal said.
Patients who received 8 mg of ondansetron intravenously along with the standard intrathecal analgesic medication reported significantly milder itching than patients who received 2 or 4 mg ondansetron or a saline placebo, Dr. Segal reported at the annual meeting of the Society for Obstetric Anesthesia and Perinatology.
In a randomized double-blinded trial, Dr. Segal and his colleagues at Brigham and Women's Hospital in Boston assigned 40 women planning neuraxial analgesia for labor into four groups. Each patient received spinal analgesia consisting of 25 mg fentanyl plus 2.5 mg bupivacaine. At the same time, they were given intravenous injections of 2, 4, or 8 mg ondansetron or the placebo.
Pruritus and pain were assessed using a 100-mm visual analog scale at the time of the spinal injection and 5,15, 30, 60, and 90 minutes thereafter, Dr. Segal said. Patients were allowed to have 5 mg IV nalbuphine as a rescue ...
- KV Pharmaceutical Company Receives ANDA Approval for 4 mg. and 8 mg....
- Press release article from: PR Newswire June 26, 2007 700+ words
Products are AB-Rated to Brand Zofran ODT(R) Marketed By GlaxoSmithKline ST. LOUIS, June 26 /PRNewswire-FirstCall/ -- KV Pharmaceutical Company announced today that it has received approval from the U.S. Food and Drug Administration to market Ondansetron 4 mg. and 8 mg. Orally Disintegrating
- Aloxi phase III clinical data summarized at international symposium.
- Newspaper article from: Clinical Trials Week July 14, 2003 700+ words
...rate among patients who received 32 mg ondansetron. During the acute phase (0-24 hours...68.6% of patients treated with 32 mg ondansetron. During the delayed phase (24-120...compared to 55.1% of patients in the 32 mg ondansetron study arm. Results from the 99-03...
- HELSINN and MGI PHARMA summarise palonosetron HCl injection (Aloxi in USA)...
- Press release article from: PR Newswire June 23, 2003 700+ words
...rate among patients who received 32 mg ondansetron. During the acute phase (0 - 24 hours...68.6% of patients treated with 32 mg ondansetron. During the delayed phase (24 -120...compared to 55.1% of patients in the 32 mg ondansetron study arm. Results from the 99-03...
- HELSINN & MGI PHARMA Summarize Palonosetron HCl Injection --Aloxi in USA--...
- Press release article from: Business Wire June 19, 2003 700+ words
...rate among patients who received 32 mg ondansetron. During the acute phase (0 - 24 hours...68.6% of patients treated with 32 mg ondansetron. During the delayed phase (24 -120...compared to 55.1% of patients in the 32 mg ondansetron study arm. Results from the 99-03...
- MGI PHARMA & HELSINN Summarize Aloxi -Palonosetron HCl Injection- Phase III...
- Press release article from: Business Wire June 2, 2003 700+ words
...palonosetron, 0.75 mg palonosetron, or 32 mg ondansetron 30 minutes prior to moderately-emetogenic...rate among patients who received 32 mg ondansetron. During the first 24 hours following...68.6% of patients treated with 32 mg ondansetron. During the delayed phase (days 2...
- Aloxi now commercially availability.
- Newspaper article from: Clinical Trials Week October 13, 2003 700+ words
...complete response rate among the 185 patients who received 32-mg ondansetron. During the acute phase (0-24 hours) following moderately...acute phase compared to 57% of 221 patients treated with 32 mg ondansetron. Consistent with medical practice, concomitant dexamethasone...
- MGI PHARMA Announces Commercial Availability of Aloxi.
- Press release article from: Business Wire September 15, 2003 700+ words
...complete response rate among the 185 patients who received 32 mg ondansetron. During the acute phase (0 - 24 hours) following moderately...acute phase compared to 57% of 221 patients treated with 32 mg ondansetron. Consistent with medical practice, concomitant dexamethasone...
- NovaDel Announces That Ondansetron Oral Spray Has Met The Key Regulatory...
- Press release article from: Business Wire March 9, 2006 700+ words
...ondansetron 8 mg oral spray is statistically bioequivalent to 8 mg ondansetron (Zofran(R)) tablet, meeting the key clinical requirement...that Zensana(TM) 8 mg dose is bioequivalent to the 8 mg ondansetron (Zofran(R)) tablet, and can be administered in multiple...