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BALTIMORE -- Low bone mineral density in older women is associated with a more than twofold increase in the risk of developing Alzheimer's disease and other forms of dementia, according to a new analysis of data from the Framingham Study cohort.
Previous research has shown an association between low bone mineral density (BMD) and low cognitive function and cognitive decline over time, Dr. Zaldy Sy Tan of Harvard Medical School said at the annual meeting of the American Geriatrics Society.
Dr. Tan and his colleagues selected 987 women and men with a mean age of 76 years and no dementia to see if they developed Alzheimer's disease and other forms of dementia during the 12-year follow-up period. To avoid the potential problems of estrogen replacement therapy compliance in women and bias issues, the researchers used BMD as a surrogate bio-marker for lifetime exposure to estrogen.
The women and men whose BMD scores were in the top 75% had 60 cases of dementia overall (including 45 with Alzheimer's disease) during more than 6,000 ...