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Avocado, soy unsaponifiables for osteoarthritis. (Alternative Medicine).
Publication: Internal Medicine News Publication Date: 01-JUN-03 Author: Walsh, Nancy
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COPYRIGHT 2003 International Medical News Group
* Blinded studies suggest that a mixture of avocado and soy unsaponifiables may provide relief of osteoarthritis symptoms.
* No serious adverse effects have been seen after 2 years of treatment.
Rationale for Use
A proprietary preparation of the unsaponifiable residues of avocado and soy oils, mixed in a 1:2 ratio, is a popular European treatment for osteoarthritis.
This product (Piascledine 300, manufactured by Pharmascience Laboratories) has been shown in animal and in vitro studies to reduce the harmful effects of interleukin-1[beta] on articular chondrocyte metabolism, possibly through enhanced expression of transforming growth factor-[beta]. It also increases production of plasminogen activator inhibitor 1, which may block the plasmin cascade that leads to destructive metalloprotease activation and promotes articular-matrix repair mechanisms. The product also stimulates collagen synthesis and inhibits production of interleukins 6 and 8...
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