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BRECKENRIDGE, COLO. -- Seizures in many epileptic women exhibit a stereotypic menses-related pattern that may have important treatment implications, Jose F. Cavazos, M.D., said at a conference on epilepsy syndromes sponsored by the University of Texas at San Antonio.
How common is this catamenial exacerbation of seizures? In one recent study led by Andrew G. Herzog, M.D., of Harvard Medical School, Boston, 87 women with localization-related epilepsy charted their seizures in three menstrual cycles. Fully 39% showed one of three predefined catamenial patterns of seizure exacerbation during at least two of the three cycles.
The three patterns characteristic of catamenial epilepsy were perimenstrual or periovulatory exacerbations during normal cycles, and exacerbations during the second half of anovular cycles (Ann. Neurol. 2004;56:431-4).
The implication is that for the many women whose seizures follow a catamenial pattern, anticipatory short-term increases in antiepileptic drug dosing may help. Or patients can add an adjunctive anticonvulsant such as acetazolamide or a benzodiazepine for 3-4 days. Several days of clomiphene are another possibility, ...
Source: HighBeam Research, Look for catamenial epilepsy pattern.(Gynecology)