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Orlistat may help in treatment of PCOS, small study shows.(Gynecology)
The weight loss drug orlistat may prove to be a useful adjunct in the treatment of polycystic ovarian syndrome, according to findings from a small randomized study that compared the drug with metformin.
"[We've] demonstrated the therapeutic potential of orlistat in PCOS," said Vijay Jayagopal, M.D., of the University of Hull (England) and his associates.
After a 12-week treatment period, 10 women treated with orlistat lost significantly more weight than 11 patients treated with metformin (a 4.7% vs. a 1% reduction) and had similar, statistically significant reductions in total serum testosterone (J. Clin. Endocrinol. Metab. 2005;90:729-33).
Neither drug produced significant reductions in fasting insulin, insulin resistance, sex hormone-binding globulin, or any of several lipid parameters studied.
In a written statement, Andrea E. Dunaif, M.D., president-elect of the Endocrine Society, said further research is needed to determine "where [weight-loss medications] will fit into the treatment of PCOS."
The current study, however, "suggests that [the] medications may be an effective treatment option for not only the obesity but also the testosterone excess associated with PCOS," said Dr. Dunaif of Northwestern University, Chicago.
Before drug treatment, all 21 patients--white women with PCOS--underwent an 8-week period of dietary modification (there were no significant changes in weight); they were then randomized to receive orlistat, which inhibits ...
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Source: HighBeam Research, Orlistat may help in treatment of PCOS, small study shows.(Gynecology)