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Injectable sumatriptan works after oral form fails.(Clinical Rounds)
VANCOUVER, B.C. -- When migraine patients who need sumatriptan to abort their headaches fail to respond to it, they should try the injectable form, Seymour Diamond, M.D., said at the annual meeting of the American Headache Society.
In an open-label study in 43 patients, injectable sumatriptan--known to be the most effective of all the triptan drugs--alleviated 91% of 123 migraines in patients who had not responded to oral sumatriptan, Dr. Diamond of the Diamond Headache Clinic, Chicago, reported in a poster presentation.
When oral sumatriptan first came out, Dr. Diamond noted that two-thirds of the patients he switched to the drug eventually went back to the injectable form because they found it more effective. That observation prompted him to do the study, he said in an interview.
"I don't start with the injectable today," he said. "But I would go immediately to the injectable" in patients who don't respond to the oral formulation.
The study involved 43 patients with migraine refractory to oral ...
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