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No effect of soy on breast proliferation in small study.(Gynecology)
SAN ANTONIO -- Consumption of soy isoflavones by postmenopausal breast cancer survivors doesn't appear to stimulate epithelial proliferative activity in the contralateral breast, according to a small pilot study.
This is a reassuring, albeit still preliminary, observation. The great majority of breast cancer patients are postmenopausal They are discouraged from using hormone therapy to manage their menopausal symptoms, which can be quite severe. Soy supplements, which are rich in phytoestrogens, are growing in popularity as a nonpharmacologic alternative, Melanie R. Palomares, M.D., noted at a breast cancer symposium sponsored by the Cancer Therapy and Research Center.
Because preclinical work had shown conflicting stimulatory and inhibitory effects of soy isoflavones on breast tissue, Dr. Palomares and her coinvestigators launched the University of Washington/Seattle Cancer Care Alliance Phytoestrogen Trial. Participants were randomized to 100 mg/day of isoflavone tablets or placebo. Ultrasound-guided core biopsies of the contralateral breast were taken at baseline and after 6 and 12 months of therapy, explained Dr. Palomares of City of Hope National Medical Center in Duarte, ...
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