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Many sickle cell patients have weak bones.(Gynecology)
SAN DIEGO -- Nearly half of adults with sickle cell anemia have osteopenia, according to results from a small study.
"Iron overloading from blood transfusion may be a relevant contributing factor, as liver iron was significantly greater in osteopenic than nonosteopenic patients," Farrukh T. Shah, M.D., said in a poster session at the annual meeting of the American Society of Hematology. "We need to look in more detail at transfused vs. nontransfused patients and see whether the iron overload story holds out."
Other potential contributory mechanisms based on previous clinical research include marrow expansion, bone infarction, delayed puberty from anemia, low vitamin D levels, iron chelation therapy, and hypogonadism.
For the study, the investigators performed dual-energy x-ray absorptiometry (DEXA) scans on 10 female and 7 male consecutive sickle cell disease patients who had previously been transfused or were currently on a transfusion program. The investigators also assessed hypogonadism, vitamin [D.sub.3], ...
- MRI method may oust liver biopsy for sickle cell.(Clinical Rounds)
- Magazine article from: Family Practice News Lowry, Fran May 1, 2008 700+ words
...ATLANTA -- Children with sickle cell disease, [beta...population of children with sickle cell disease at St. Jude...were female, 35 had sickle cell disease, 8 had [beta...with quantification of liver iron content within 30 days...
- Research data from University of California update understanding of sickle cell...
- Newspaper article from: Blood Weekly March 19, 2009 700+ words
...overloaded patients with sickle cell disease (SCD) and...between splenic and liver iron-this association was...California (see also Sickle Cell Anemia). The researchers...Overloaded Patients With Sickle Cell Disease and Thalassemia...
- SICKLE CELL DISEASE ROBS YEARS FROM LIFE.(LIFE & LEISURE)
- Newspaper article from: Albany Times Union (Albany, NY) February 15, 1994 700+ words
...100,000 Americans who suffer from sickle cell disease, an incurable, inherited blood...the body giving serious pain." While sickle cell disease is the most common genetic disorder...black community. Even among blacks, sickle cell often looms as mysterious as it is chronically...
- Sickle cell anemia.(Causes and Treatment)(Disease/Disorder overview)
- Clinical Reference Systems January 1, 2006 700+ words
What is sickle cell anemia? Sickle cell anemia is an inherited disease that causes abnormal red blood cells. It is a lifelong disease. Sickle cell anemia is most prevalent among people who are African, African...
- Sickle Cell Disease Awareness Stamp to be Issued by U.S. Postal Service; Stamp...
- Press release article from: PR Newswire August 27, 2004 700+ words
...Service will issue the 37-cent Sickle Cell Disease Awareness postage stamp on Sept. 29 in Atlanta at the Sickle Cell Disease Association of America...Affecting one in 12 African Americans, sickle cell disease damages blood cells by changing...
- Sickle cell trait.(Causes and Treatment)(Disease/Disorder overview)
- Clinical Reference Systems Muller, William January 1, 2006 700+ words
What is sickle cell trait? Sickle cell trait is not the same as sickle cell disease. If your child has sickle cell trait, it means that he or she has one abnormal gene that causes sickle cell disease. For someone to have sickle cell disease...
- Sickle Cell Disease Awareness to Be Highlighted by New U.S. Postage Stamp;...
- Press release article from: PR Newswire September 26, 2003 700+ words
...U.S. Postal Service unveiled the Sickle Cell Disease Awareness commemorative stamp...at the 31st annual convention of Sickle Cell Disease Association of America Inc. Hosted by the Sickle Cell Disease Foundation of California...
- Sickle Cell Disease
- Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed. Bojanowski, Jennifer; Frey, Rebecca January 1, 2006 700+ words
Sickle Cell Disease Definition Sickle cell disease describes a group of inherited blood disorders characterized...complications due to associated tissue and organ damage. Because sickle cell diseases are characterized by the rapid loss of red blood...
Source: HighBeam Research, Many sickle cell patients have weak bones.(Gynecology)