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Research conducted at A. Forand and co-authors has provided new information about apoptosis.
"Neonatal gonocytes are the precursors of both spermatogonial stem cells and spermatogonia; thus, any persistant DNA damage in these cells may lead to heritable mutations. We investigated the response of male mouse neonatal germ cells to ionizing radiation," researchers in France report (see also Apoptosis).
"Both gonocytes and spermatogonia died in large numbers by apoptosis. However, we found that the gonocytes were significantly more sensitive than spermatogonia and somatic cells to radiation-induced double-strand breaks ( DSBs), as assayed by the number of gamma-H2AFX foci. In contrast, gonocytes irradiated in G2 phase seemed to repair DSBs faster than spermatogonia. Moreover, when irradiated in S phase, gonocytes arrested their cell cycle at the G1/S phase transition, whereas spermatogonia were mostly blocked in G2/M phase. Despite these differences, both cell types expressed high levels of proteins involved in DSB signaling and repair. Within the first hours after irradiation, the expression of Atr, Mre11a, H2afx, Xrcc6, and Xrcc4 was downregulated in neonatal spermatogonia, whereas, in gonocytes, most gene expression was unaffected," wrote A. Forand and ...
- New stem cell research study findings have been reported from A. Forand et al.
- Newspaper article from: Biotech Week October 14, 2009 700+ words
"Neonatal gonocytes are precursors of spermatogonial...the death machinery in neonatal gonocytes. Their death was correlated...pathway," wrote A. Forand and colleagues. The...stem cell precursors." Forand and colleagues published...
- Studies conducted at A. Forand et al on spermatogenesis recently published.
- Magazine article from: Women's Health Weekly May 21, 2009 700+ words
...old mice had no effect," wrote A. Forand and colleagues. The researchers concluded...neonatal spermatogonial-stem cell pool." Forand and colleagues published their study in...For more information, contact A. Forand, CEA, SCSR, iRCM, DSV, Laboratory...
- Doug Forand, Marc Lapidus and Nathan Smith.(Who's where in the political world...
- Magazine article from: Politics Magazine May 1, 2008 700+ words
Doug Forand, Marc Lapidus and Nathan Smith have left the New York State Democratic...Horse Strategies. They've already signed the state DSCC as a client. Forand ran Alan Hevesi's campaign for state comptroller in 2002. Lapidus was...
- Data on stem cell research discussed by researchers at McGill University,...
- Magazine article from: Stem Cell Week April 20, 2009 700+ words
...genetic identity of gonocytes, providing a description of the 'common' gene expression profiles of fetal and neonatal gonocytes, as well as information on the main regulatory factors of gonocyte functions," wrote M. Culty and colleagues...
- Hartford, Conn., Children's Science Museum to Reinvent Itself.
- Newspaper article from: Hartford Courant (Hartford, CT) May 14, 2004 700+ words
...elsewhere in West Hartford, Edward J. Forand Jr., the president and chief executive...renewed focus on young children, and Forand said it planned to become a "feeder...science center" at Adriaen's Landing, Forand said Thursday. "There are some things...
- Thacker takes over command at New River.
- Newspaper article from: Daily News (Jacksonville, NC) July 8, 2006 700+ words
...another three years. Col. Stephen L. Forand, who has held the post since June 2003...people in attendance comfortable reminded Forand, 51, of the June evening when he took...It's a beautiful Carolina evening," Forand said after he shouted good evening into...
- A local historian's debt to al- Tabari: The case of al-Azdi's Ta'rikh...
- Magazine article from: The Journal of the American Oriental Society Robinson, Chase F. October 1, 2006 700+ words
In 1969 Paul Forand published in this journal the results...late Umayyad and early Abbasid period, Forand concluded with some historiographic comparisons...rikh, which appeared shortly after Forand's article was published, (3) nothing...
- From longtime teammates to future Ivy League rivals
- Newspaper article from: The Boston Globe Steve Crowe November 8, 2009 700+ words
...level and have worked hard at that." Forand's a net win for Nichols squad Judging...s hard to imagine that Krista-Jean Forand is playing goalie for the first time for...and the backup goalie quit the team, Forand volunteered to play goal. "She came...
