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Scientists at National Cheng-Kung University, Medical Department target adipose tissue.
"Adipocyte plays an important role in lipid regulation in mammals. Understanding of adipocyte differentiation becomes a key issue for the development of anti-obesity agent," investigators in Tainan, Taiwan report (see also Adipose Tissue).
"Glucocorticoids (GCs) regulate lipid metabolism through promoting lipogenesis in adipose tissue. Ginsenoside Rh2, with a similar chemical Structure as M, shows antidiabetic, anti-inflammatory, and anticancer actions both in vivo and in vitro. However, effect of Rh2 On glucocorticoid receptor (GR) for an increase of adipogenesis like GCs remains unclear. In the present study, we employed ginsenoside Rh2 to investigate the changes in adipogenetic process of 3T3-L1, one of the widely used preadipocytes, through activating GR or not. In leuciferase assay, we found that ginsenoside Rh2 induced GRs transitivity in a way as dexamethasone, which was deleted by RU486 at concentrations sufficient to block GR. Moreover, 3T3-L1 preadipocytes were differentiated into adipocytes by adipogenic induction medium containing 0.01 to 1 mc M of ginsenoside Rh2. Also, RU486 blocked this adipogenesis induced by ginsenoside Rh2 or dexamethasone. The obtained results Suggest ...
- Study results from National Cheng-Kung University, Medical Department broaden...
- Newspaper article from: Blood Weekly November 13, 2008 700+ words
...wrote S.S. Chang and colleagues, National Cheng-Kung University, Medical Department. The researchers...information, contact P.C. Lee, National Cheng Kung University, National Cheng Kung University Hospital, College Medical...
- Study findings from National Cheng-Kung University provide new insights into...
- Newspaper article from: Blood Weekly December 11, 2008 700+ words
...P. Chuang and colleagues, National Cheng-Kung University (see also Kidney Transplants...information, contact P.C. Lee, National Cheng Kung University, College Medical, National Cheng Kung University Hospital, Division Organ Transplantation...
- National Cheng-Kung University details research in applied physics.
- Newspaper article from: Physics Week May 12, 2009 700+ words
...Chen and colleagues, National Cheng-Kung University. The researchers...contact Y.C. Chen, National Cheng Kung University, Dept. of Physics...Voltage, Physics, National Cheng-Kung University. This article was...
- National Cheng-Kung University details research in life sciences.(Report)
- Newspaper article from: Mental Health Weekly Digest February 2, 2009 700+ words
...Lin and colleagues, National Cheng-Kung University (see also Life Sciences...contact P.W. Gean, National Cheng Kung University, Institute Basic...Anxiety Disorder, National Cheng-Kung University. This article was...
- National Cheng-Kung University details research in computer systems.
- Newspaper article from: Computer Weekly News July 2, 2009 700+ words
...Chen and colleagues, National Cheng-Kung University. The researchers...contact P.C. Chen, National Cheng Kung University, Dept. of Electrical...Computer Systems, National Cheng-Kung University. This article was...
- National Cheng-Kung University reports research in wireless...
- Newspaper article from: Journal of Mathematics August 18, 2009 700+ words
...Lai and colleagues, National Cheng-Kung University. The researchers...contact K.C. Lai, National Cheng Kung University, Dept. of Electrical...Wireless Communications, National Cheng-Kung University. This article was...
- National Cheng-Kung University details research in antennas and...
- Newspaper article from: Journal of Engineering August 5, 2009 700+ words
...Lee and colleagues, National Cheng-Kung University. The researchers...contact K.C. Lee, National Cheng Kung University, Dept. of Systems...and Propagation, National Cheng-Kung University. This article was...
- National Cheng-Kung University reports research in nanosystems.(Report)
- Newspaper article from: Nanotechnology Weekly November 16, 2009 700+ words
...Tsai and colleagues, National Cheng-Kung University. The researchers...contacting N.C. Tsai, National Cheng Kung University, Dept. of Mech Engineering...Nanotechnology, National Cheng-Kung University. This article was...
Source: HighBeam Research, Scientists at National Cheng-Kung University, Medical Department...