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Research results from J. Sun and colleagues update understanding of DNA vaccines.
"In higher eukaryotes, introns are usually required for efficient pre-mRNA processing. However, some viruses have alternative approaches involving posttranscriptional regulatory elements (PREs) to enhance intronless heterologous gene expression through enabling stability and 30 end formation, and to facilitate the nucleocytoplasmic export of unspliced mRNAs," researchers in Beijing, People's Republic of China report (see also DNA Vaccines).
"In the current study, we compared the human cytomegalovirus (hCMV) immediate/early (IE) intronA, as well as virus-derived PREs-the PRE of Hepatitis B virus (HPRE) and Woodchuck Hepatitis virus (WPRE) on their ability to enhance antigen gene expression in vitro and immune responses induced by DNA vaccination in animal. Among all the constructs, the plasmids carrying the HPRE element showed the highest gene expression level in both in vivo and in vitro models. During immunization of mice with low doses (10 mg) of HIV-1 DNA vaccine, only -intronA/+HPRE and +intronA/+HPRE vaccine constructs induced anti-Gag antibodies, although the +intronA/+WPRE construct also elicited antigen-specific cellular immune responses. In addition, pInHGag (+intronA/+HPRE) at a 10 mg dose could induce higher anti-Gag antibody level than that induced by pGag (+intronA/+HPRE) or pInGag (+intronA/+HPRE) at 40 ...
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...clinical trial data demonstrating that DNA vaccines can safely achieve significant immune...H5N1 pandemic influenza in humans. DNA vaccines are fundamentally different from conventional...formulated H5N1 pandemic influenza DNA vaccines demonstrated for the first time that...
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...potency of next generation vaccines, namely DNA vaccines. We believe DNA vaccines promise not only protective but also therapeutic...have historically hindered the development of DNA vaccines. In the past a barrier to achieving the promising...
- Inovio Biomedical Grants Wyeth Pharmaceuticals License to Develop Infectious...
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...leader in enabling the development of DNA vaccines using electroporation-based DNA delivery...applications of certain therapeutic DNA vaccines. Under the terms of the agreement...R]) DNA Delivery System to develop DNA vaccines for the treatment of debilitating diseases...
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...QIA) to exploit the potential of DNA vaccines in aquaculture. Based on information...applications. The commercialization of DNA vaccines is highly dependent on the availability...certain patents which cover the use of DNA vaccines in aquaculture to control viral and...
- DNA vaccines: improvements pending.(Brief Article)(Statistical Data Included)
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...autoimmune diseases and allergies. Naked DNA vaccines appear to offer the promise of long...A major reason for the interest in DNA vaccines is the generic delivery system on which...which can revert to an infective form, DNA vaccines cannot cause an infection. Moreover...
- Research Efforts Focused on Developing DNA Vaccines.
- Press release article from: Business Wire February 23, 2005 700+ words
...Global R&D efforts focus on DNA vaccines that are capable of achieving potent...procedures," says Aditya. "Moreover, all DNA vaccines use similar fermentation, purification...protein production." In addition, DNA vaccines generate a strong cell and antibody...
Source: HighBeam Research, Research results from J. Sun and colleagues update understanding of...