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PHILADELPHIA -- A short course of a glucocorticoid provides rapid and sustained pain relief for painful uterine leiomyomas in pregnancy, according to a chart review of six patients presented in poster form at the annual meeting of the American College of Obstetricians and Gynecologists.
"NSAIDs are most typically given for painful fibroids during pregnancy, but I have not found them to be nearly as effective as prednisone or dexamethasone," said Dr. Stephen Friedman of the department of perinatology at Providence St. Vincent Medical Center, Portland, Ore. Narcotic analgesics such as oxycodone with acetaminophen and codeine are also used for painful fibroids, but they provide only limited symptomatic relief, he added.
"Conventional treatment" for painful fibroids also included bed rest, Dr. Friedman said. Other practitioners have proposed the use of epidural narcotics, open excision, or laparoscopic excision. "In our experience, conventional treatment has provided only limited symptomatic relief," he said.
"Prednisone is preferred over dexamethasone because it doesn't cross the placenta--other steroids will cross and include the ones used to induce fetal lung maturity," he noted during the meeting.
The retrospective chart ...
Source: HighBeam Research, Chart review of six patients; Small study: glucocorticoids can treat...