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Multivariate analysis: persistence of high-risk HPV linked to STD coinfection.(Gynecology)
PHILADELPHIA -- Infection with more than one type of human papillomavirus and Chlamydia trachomatis coinfection are both associated with persistence of high-risk human papillomavirus types. Erika Samoff, Ph.D., reported.
In a study of 282 adolescent females at a primary care clinic in a public hospital, 43% of those with a high-risk human papillomavirus (HPV) infection had evidence of the same high-risk type of HPV, such as 16 or 18, after 6 months. After 1 year, 10% had evidence of their previously detected high-risk HPV infection, she said at a conference on STD prevention sponsored by the Centers for Disease Control and Prevention.
A multivariate analysis revealed that the subjects with chlamydia coinfection were 5.1 times more likely to have a persistent infection with a high-risk HPV type than were teens without the coinfection.
Also, teens infected with more than one type of HPV were 3.6 times as likely to have a persistent high-risk infection, said Dr. Samoff, an epidemic intelligence service officer with the CDC in Atlanta.
Persistence was defined as definite detection of the same HPV type at two sequential visits separated by at least 6 months.
"Always screen for chlamydia with teens and young women, especially in the presence of HPV. Our study is a reinforcement of that message," she said at the meeting. "We know that persistence of HPV infection is strongly associated with development of cervical cancer. Our study suggests that chlamydia might facilitate progression to cervical cancer."
Dr. Samoff also observed that HPV is "necessary but not sufficient to cause cervical cancer."
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Source: HighBeam Research, Multivariate analysis: persistence of high-risk HPV linked to STD...