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Possible immunosuppression: sunlight associated with higher risk of HPV.(News)

OB GYN News

| July 01, 2004 | Zoler, Mitchel L. | COPYRIGHT 2004 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

ORLANDO, FLA. -- A high level of sun exposure was associated with an increased rate of cervical infection with human papillomavirus, Dr. William J.M. Hrushesky reported at the annual meeting of the American Association for Cancer Research.

He and his associates reviewed the results of more than 900,000 cervical Pap smears that were collected during 1983-1998 from women in the Netherlands by the Leiden Cytology and Pathology Laboratory. These specimens were considered to be positive for active infection by human papillomavirus (HPV) if they contained koilocytic epithelial cells and multinucleate cells.

The monthly distribution of specimens positive for HPV was compared with the monthly rate of sexual activity in the Netherlands, and with monthly changes in solar UV fluence. Sexual activity was extrapolated from birth records and conception frequency. Solar UV fluence was calculated from weather records, said Dr. Hrushesky, a senior clinical investigator at the Veterans Affairs Medical Center. Columbia, S.C.

The consistent peak for HPV positivity each year correlated with peak solar fluence, which occurs in August in the ...

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